منابع مشابه
Gene therapy for pituitary tumors.
Pituitary tumors are the most common primary intracranial neoplasms. Although most pituitary tumors are considered typically benign, others can cause severe and progressive disease. The principal aims of pituitary tumor treatment are the elimination or reduction of the tumor mass, normalization of hormone secretion and preservation of remaining pituitary function. In spite of major advances in ...
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Background & Importance: The aim of this study was to demonstrate the result of transsphenoid microsurgery for Cushing disease in our center and comparing the results in details with other articles, to achieve the best decision for patients management in future. Case Presentation: Between 1991 to 2015, 50 patients suffering from Cushing disease were operated. Before operation, endocrine t...
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Brain tumors comprise a broad spectrum of biological and clinical entities making it unlikely for any single therapeutic approach to be universally applicable. In particular, malignant glioblastoma multiforme have defied all current therapeutic modalities. Gene therapy offers the potential to augment current neurosurgical, radiation and drug treatments with little increase in morbidity. Many th...
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Cancer is now an important target for gene therapy. Most animal experiments were done with the use of transplanted tumors produced by implantation of cell lines, an approach that ignores histologic and anatomic specificity of organs. Chemically induced orthotopic models are much superior to the subcutaneous transplanted models with respect to the evaluation of the efficiency of gene transfer an...
متن کاملSuicide gene therapy for plasma cell tumors.
Suicide gene therapy for plasma cell tumors was attempted in severe combined immunodeficient (SCID) mice injected with human myeloma cell lines. Initially, a ganciclovir-induced bystander effect was observed in vitro using myeloma cells transduced with a herpes simplex thymidine kinase (HSVtk) gene. Transduced cells injected subcutaneously (SC) into SCID mice could be eradicated by the administ...
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ژورنال
عنوان ژورنال: Current Gene Therapy
سال: 2005
ISSN: 1566-5232
DOI: 10.2174/156652305774964721